![]() ![]() Using glue stick I glued two postcards together back-to-back to make the covers extra strong, but using just one postcard or reinforcing a postcard with a same-size piece of cardstock is fine too. I found some great 4 ¼” x 6″ postcards of Boston at a local bookstore. You can also make one before your trip either way, you can create or decorate pages with ephemera that you collect on your journey-maps, bags, brochures, business cards, etc. I love making these while I’m on vacation or traveling, and sometimes I take along a basic supply kit so I can bind on the go. They’re made with ordinary postcards for covers and paper scraps for the inside pages, and they’re sewn with a simple version of a tacket binding. These easy mini travel journals are perfect for summer. I made these mini travel journals out of postcards and scrap paper. The satisfaction you’ll feel when you’ve created something beautiful and functional is incomparable, and soon you’ll be making your own art journals that perfectly suit your needs. ![]() If you’ve never made a book before I assure you it’s not as intimidating as it may look. A book can be a diary, art journal, sketchbook, travel journal, and more-there are no limits. When I discovered bookbinding and book art years ago I felt like a part of my brain suddenly lit up, and it has stayed illuminated ever since.īooks represent endless possibilities and opportunities they can be functional, an art piece, or both. I love every facet of mixed media, but there is a special place in my heart for handmade books.
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![]() Our algorithm employs a convolutional neural network, a class of deep learning already commonly used in visual imagery analysis, recommender systems, and natural language processing. In order to improve the detection and classification of binding pockets in proteins, we developed a new computational tool, DeepDrug3D. Annotating ligand-binding sites is complicated by a fact that the same small molecule often binds to similar pockets but located in different proteins. A typical ligand-binding site is a small pocket formed by a few residues while the remaining protein structure acts as a framework providing the correct orientation of binding residues. ![]() Small organic ligands bind to the locations of chemical specificity and affinity on their protein targets, called binding sites. DeepDrug3D is available as an open-source program at with the accompanying TOUGH-C1 benchmarking dataset accessible from. Interestingly, the analysis of strongly discriminative regions of binding pockets reveals that this high classification accuracy arises from learning the patterns of specific molecular interactions, such as hydrogen bonds, aromatic and hydrophobic contacts. The current implementation of DeepDrug3D, trained to detect and classify nucleotide- and heme-binding sites, not only achieves a high accuracy of 95%, but also has the ability to generalize to unseen data as demonstrated for steroid-binding proteins and peptidase enzymes. It employs a state-of-the-art convolutional neural network in which biomolecular structures are represented as voxels assigned interaction energy-based attributes. In this communication, we present DeepDrug3D, a new approach to characterize and classify binding pockets in proteins with deep learning. Deep learning is attracting a significant attention due to its successful applications in a wide range of disciplines. On that account, novel algorithms to accurately classify binding sites are needed. These research efforts pose significant challenges owing to the fact that similar pockets are commonly observed across different folds, leading to the high degree of promiscuity of ligand-protein interactions at the system-level. Comprehensive characterization of ligand-binding sites is invaluable to infer molecular functions of hypothetical proteins, trace evolutionary relationships between proteins, engineer enzymes to achieve a desired substrate specificity, and develop drugs with improved selectivity profiles. Next: Want to share content between your Android and PC? Click on the next link to check out our top 5 Clipboard apps that sync data between Windows 10 and Android. If you know of more deserving clipboard managers, share them in the comments below. A good clipboard manager can save your work from being lost when things go wrong with an app or site. Whether it’s clippings from the web or the full document you want to share with others. Sometimes, saving your clipped content can help in the long run. You can master the Copy and Paste functions, but you will need a reliable clipboard manager to optimize your productivity. You may struggle a bit at first, but then you can make the most of its abilities. Copy’em is a paradise for people who love keyboard shortcuts and don’t mind using them all on macOS. This app offers everything from recording your clips to managing them the way you want. Of course, the clipboard can hold all kinds of data, from text to images. One of the coolest things about this app is that it includes a built-in screenshot tool that you can use as a quick note taker. I recommend getting it from the SetApp Store, which has a monthly subscription fee of $9.99.Īnother useful clipboard manager that lets you use customized shortcuts and automatic favorites for clips. However, you get two more productivity apps with it. If you’re just looking for a clipboard manager, this amount may seem like a lot. Unclutter offers a free 7-day trial, after which you can pay $19.99 to unlock its full potential. IS there something like that for osx I did look up the top clipboard managers on google, but none of them fill those requirements. Meanwhile, the file center can store your files that you don’t want to see in your desktop view. Windows has something called a clipboard manager, where instead of pressing control v you can select windows + v, and it'll drop down your clipboard history, and you can select what you want to paste. You can also use the notebook to jot down snippets of information. Unclutter’s interface is very interesting for you to have File Center manage all temporary files in an area like a cabinet. You can copy anything like Just define a hotkey and it will slide down from the menu bar. Of course, you can add text, links, images, code, etc. You can also save entries later and edit them at any time. Clipboard manager saves all entries and lets you edit them the way you want. Yes, Unclutter lives up to its name to keep the clipboard instantly accessible and fast. Because I'm always nervous that ClipMenu will break, I hope this review will motivate Cop圜lip developers to step up and 'copy' the versatility of ClipMenu because a capable clipboard manager is an essential operating feature for me (and I think anyone that bothers to use it a while will surely then be spoiled).Why settle for one when you can have three apps in one? The Unclutter clipboard manager includes a notepad and a file center to store temporary files. Finally, that amazing little app hasn't been updated since 2014 but still works flawlessly up thru at least Catalina (I haven't upgraded to Big Sur but expect it will continue working well). I have Copy Clip and you don't! Me stupid? What took YOU so long to finally get here?Ĭop圜lip functions fine as a basic clipboard manager BUT it still doesn't work as well as the similar free ClipMenu app which has very useful "Snippets", "Shortcuts" and "Actions" (all very useful but the user doesn't have to bother because they don't complicate the interface or basic usability) plus configuration of almost everything imaginable, from the menu bar icon choice to what types of files may be clipped to the quantity of clipped items stored to subfolders on the menu etc etc. And for those who are thinking, "How stupidi of that guy to not have a back up of those 29 pages!!", consder the following. I mean if you're readng this and you do not yet have copy clip installled, please do it now. My astoundment stems from my totally forgetting about thse college days when in a matter of seconds, a twety-nine page research paper could be gone with no chance of retrieval all because I copied to clipboard, deleted one graphic from the paper, accidentally copied a second graphic to the clipboard and POOF!! - 29 pages gone forever. It is like I no longer write, create or design in fear of losing stuff. ![]() No kidding! My copy clip is set to temember the last 80 items I copied to clipboard. I was simply astounded when I was asked to do a review for Copy Clip! The invitation took me back to a time "pre- CC" when I didn't have the ability to see any history of my clipboard, let alone the power to go back and paste a clipboard item that I copied to the clipboard but have copied 79 items since. ![]() Many popular financial news websites provide RSS news feeds free of charge. StockSpy uses the extremely popular RSS feed standard. You can also add individual feeds to a specific stock. Our innovative feed template system allows you to setup a news feed once and use it for every symbol in your list. StockSpy allows complete customization of news sources. This allows you to browse detailed information about specific this app having to type a symbol. StockSpy provides easy access to information from the top Investor websites with Symbol Specific website links. We have taken this great innovation we call NewsCharts from Stock Spy for the desktop (available on PC + Mac! See more details at ) and brought it to the iPhone! This means if you find a day which had interesting price change (like a big pop or drop) you can easily find out what news was "driving" the stock. As you flick through the news articles the NewsChart highlights the currently active bar for the visible news items in the news list. NewsChart technology shows you how the news volume changes over time when in landscape mode. Start making more money because you have the information to make smart trades. Say goodbye to wasting time by manually checking several news websites and still not getting the whole picture on your this app. Stop losing money because you're not getting all the important news & information about your this app. ![]() This provides you with more complete information when making your important investment decisions. With StockSpy you can automatically load several top quality RSS news feeds for each of the symbols you're tracking. StockSpy for iPhone simplifies tracking stock market news for the companies you follow and allows you to VISUALIZE how the news affects stock prices with NewsCharts! ![]() Now more than ever you need to be on top of what is happening with your investments. ►Hit 1st on Finance Top Grossing for iPad! ►Featured in the “Incredible iPad Apps for Dummies” book by Bob “Dr. ►Featured by Apple in Finance New & Noteworthy! ◆ StockSpy keeps getting more awesome with FREE upgrades! ◆ New portfolio tracking and technical analysis features. ◆ New Version - Now with cloud sync between iPhone, iPad & Mac!* ◆ You can adjust the “Control” and “Command” functions and make it behave like Windows in this way. If you are unfamiliar with keyboard layout, Mac OS X has a feature that allows you to reassign the modifier key. ![]() To select everything, use “Cmd + A”, then “Cmd + C” to copy, then “Cmd + V” to paste. Although the keyboard has a Control button, most keyboard shortcuts are performed via the “Command” button. When it comes to Mac OS X, the settings are completely different. To select everything, use “Ctrl + A”, then “Ctrl + C” to copy and “Ctrl + V” to paste. The Control key is used for most keyboard shortcuts in Windows. You might have trouble adjusting to the keyboard, particularly the Control and Command keys, if you have recently converted to Mac OS X from a conventional Windows operating system that you have used all your life. Have you connected your Mac computer to a Wi-Fi printer yet? It’s easier than you think.Check How to Switch the Functionality of Command and Control Keys on MacBook Keyboard This is going to make using that keyboard a lot simpler in programs like Microsoft Office. You should now be to able to use Mac’s Command action by pressing the Ctrl key on your Windows keyboard. Step 7: Click the OK button to save your changes. Step 6: Click the drop-down menu to the right of the Control Key option, then choose the Command option. Step 5: Click the drop-down menu to the right of the Command Key option, then choose the Control option. Step 4: Click the Modifier Keys button at the bottom of the window. Step 3: Click the Keyboard tab at the top of the window. Select the Keyboard option from the View menu Step 2: Click View at the top of the screen, then click Keyboard. Step 1: Click the Apple icon at the top of the screen, then click System Preferences. Simply follow the steps below to re-assign the Command action to the Ctrl key on your own Mac computer. But the Ctrl key is a lot more convenient, so I am going to use that instead. If you looked at the picture of my keyboard in the image above, then you can see how awkward it would be to use the Windows key every time I needed to copy, paste or select all. Plus it matches the Mac Mini a lot better.Īssign the Mac OS X Command Action to a Different Key Or you could just buy a Mac keyboard and make all of this unnecessary. That Windows key is not a good option for using the Command action So continue reading below to learn how to switch the Command action to a different key on your Windows keyboard when you are using the Mac operating system. Luckily this setting can be changed to something more convenient, such as the Ctrl key. Especially for something as integral to your usage of the operating system as the Command action. OS X assigns the Command action to the Windows key on a Windows keyboard, and that key is often not very convenient. But there is one slight problem with the default configuration. I have a Samsung monitor, Microsoft mouse and Dell keyboard hooked up to mine right now, and everything is working fine. ![]() Fortunately these do not need to be Mac-specific. You need to supply your own keyboard, mouse and monitor. ![]() ![]() But the Mac Mini only comes with a computer and a power plug. It is one of the most affordable Mac options and it has a very small form factor. Many people that are looking to purchase a Mac computer choose a Mac Mini. Last updated on May 11th, 2023 at 10:38 am ![]() For the purpose of this cheat sheet, we will break them down into categories in the following rows. These logs cover everything from system logs to security logs to application and service logs. This location is the storage point for the Windows event logs. ![]() System logs designed to record security events for incident investigation Scheduled tasks (optimal for identifying persistence) Security-related events such as user logins, root user activity and PAM output var/log/secure(debian /var/log/auth.log) Stores all global system activity data, including startup messages var/log/messages(debian /var/log/syslog) Keep this list handy, especially if your SOC’s maturity level needs a little boost! LINUX LOGS This will allow your security operations team to know which log files are critical for activities such as monitoring, auditing, analysis, threat hunting, and overall security program improvement. That is why Google Cloud Technical Solutions Engineer Ivan Ninichuck compiled the below cheat sheet of go-to Windows and Linux logs and and mapped them to key tactics and techniques of the MITRE ATT&CK framework. Knowing which events are indicative of something major and worthy of further investigation, like a security breach, isn’t always self-evident. That’s because your logs are likely capturing huge volumes of data. But it is not always easy for teams to know where they should be looking. Here is where Linux and Windows event logs come in, providing that essential observability into the goings-on across your organization’s network and digital footprint. Being aware of the details of users, assets, known threats, and specific vulnerabilities present across security, network, server, application and database sources allows security operations teams to act quickly and decisively to address possible risks. Within the security operations center, visibility is everything. ![]() If you absolutely have to have Bruce Lee now because you have no desire to play as anyone else in EA Sports UFC, you can purchase all four of the weight classes for 5.99 outright, or 1.99 for. 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You have reached a degraded version of because you're using an unsupported version of Internet Explorer.įor a complete experience, please upgrade or use a supported browser Brock Lesnar - EA Sports UFC 4 - Epic Fight. The Bruce Lee Bundle in 4 Weight classes costs 6 or you can buy each Bruce Lee character individually per weight class at 2 per character. ![]() ![]() The worms are back in their most destructive game yet. With a gorgeous, hand-drawn 2D look, brand new weapons, the introduction of crafting, vehicles and buildings plus the return of some much-loved classic weapons and gameplay, Worms W.M.D is the best worms experience ever. ![]() Use new vehicles to cause chaos amongst the enemy ranks and use buildings to gain the tactical advantage as you try to dominate the battlefield! Work your way through 30 campaign levels of increasing difficulty using the huge arsenal of new and classic weapons at your disposal. 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I have read so many positive reviews about how this product has helped many people with issues concerning their Android or iOS smartphone. ![]() Vet research goes hand in hand with increasing your education rating and your guests’ willingness to donate money (the primary source of income). Now, go into the “Nature” menu (found at the bottom of the screen) and use the filter button to show only those Continents and Biomes.
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